Catalyst-free site-selective cross-aldol bioconjugations

نویسندگان

چکیده

We present catalyst-free “green” site-selective protein bioconjugations that utilise aldol condensations and are compatible with click chemistries, construct a nanobody-derived bioconjugate capable of selectively labelling prostate cancer cells.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A dual site catalyst for mild, selective nitrile reduction.

We report a novel ruthenium bis(pyrazolyl)borate scaffold that enables cooperative reduction reactivity in which boron and ruthenium centers work in concert to effect selective nitrile reduction. The pre-catalyst compound [κ(3)-(1-pz)2HB(N = CHCH3)]Ru(cymene)(+) TfO(-) (pz = pyrazolyl) was synthesized using readily-available materials through a straightforward route, thus making it an appealing...

متن کامل

An efficient catalyst-free Mukaiyama-aldol reaction of fluorinated enol silyl ethers with tryptanthrin.

We report an efficient Mukaiyama-aldol reaction of tryptanthrin with fluorinated enol silyl ethers, which is carried out in methanol without the use of any catalyst. This method is applied to the total synthesis of the difluoro analogues of the natural product Phaitanthrin B.

متن کامل

A new application of nano-graphene oxide as a heterogeneous catalyst in crossed-aldol condensation reaction under solvent-free conditions

Nano-graphene oxide was synthesized by the oxidation of graphite powders. The structural nature of the nano-graphene oxide was characterized by a variety of techniques including XRD, TEM, FT-IR and UV/Vis. The functional groups on its basal planes and edges of nano-grahene oxide play important role in catalytic activity. The catalytic activity of nano-graphene oxide was investigated on Crossed-...

متن کامل

Proline-modified DNA as catalyst of the aldol reaction.

DNA templated synthesis has emerged as a powerful tool to steer reactivity by modulating nature s approach to increase the effective molarity of the reactants. By making recourse to the inherently selective duplex formation properties of cognate DNA strands, small molecule reactants are brought to close proximity increasing the effective molarity and thereby significantly accelerating chemical ...

متن کامل

A new application of nano-graphene oxide as a heterogeneous catalyst in crossed-aldol condensation reaction under solvent-free conditions

Nano-graphene oxide was synthesized by the oxidation of graphite powders. The structural nature of the nano-graphene oxide was characterized by a variety of techniques including XRD, TEM, FT-IR and UV/Vis. The functional groups on its basal planes and edges of nano-grahene oxide play important role in catalytic activity. The catalytic activity of nano-graphene oxide was investigated on Crossed-...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Green Chemistry

سال: 2022

ISSN: ['1463-9262', '1463-9270']

DOI: https://doi.org/10.1039/d2gc02292c